Melpo Christofidou-Solomidou, PhD - Research Professor of Medicine - University of Pennsylvania


University of Pennsylvania, Department of Medicine
Pulmonary, Allergy and Critical Care Division


B.S. (Biology) State University of New York at Stony Brook, Long Island, New York, 1983. M.S. (Cell Biology) Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987. Ph.D. (Cell Biology) Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.

Description of Research Expertise

The theme of Dr. Christofidou-Solomidou's research is pulmonary inflammation and cell adhesion molecule regulation/expression. Projects involve the development of oxidant-induced acute and chronic lung injury animal models for the study of diseases such as ARDS, sepsis, radiation induced pneumonitis/fibrosis, and oxygen toxicity. Specific projects focus on the development of antioxidant methodologies such as immune conjugates for the targeting of anti-oxidant enzymes such as Catalase and Superoxide Dismutase to the pulmonary endothelium using antibodies to endothelial antigens. Recent work extends to the use of dietary alternative antioxidant agents such as curcumin, flaxseed or phenolic compounds in ameliorating acute and chronic oxidative lung disease.

Selected Publications

Mishra OP, Popov AV, Pietrofesa RA, Andrake M, Nakamaru-Ogiso E, and Christofidou-Solomidou M: Synthetic Secoisolariciresinol Diglucoside (LGM2605) Inhibits Myeloperoxidase Activity in Inflammatory Cells. Biochim Biophys Acta MARCH 2018.

Thomas J. Goodwin, Melpo Christofidou-Solomidou: Oxidative Stress and Space Biology: An Organ-Based Approach. International Journal of Molecular Sciences. MDPI, Basel, Switzerland, 19: 959, MARCH 2018.

Pietrofesa RA, Chatterjee S, Park K, Arguiri E4, Albelda SM, Christofidou-Solomidou M.: Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Reduces Asbestos-Induced Cytotoxicity in an Nrf2-Dependent and -Independent Manner. Antioxidants (Basel) 7(3), MARCH 2018.

Mohanty SK, Gonneau C, Salamatipour A, Pietrofesa RA, Casper B, Christofidou-Solomidou M and Willenbring JW: Siderophore-mediated iron removal from chrysotile: Implications on asbestos toxicity reduction and bioremediation. Journal of Hazardous Materials 341: 290-296, JAN 2018.

Slava Rom, Viviana Zuluaga-Ramirez, Nancy Lee Reichenbach, Michelle A Erickson, Malika Winfield, Sachin Gajghate, Christofidou-Solomidou M, Kelly L Jordan-Sciutto, Yuri Persidsky: Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: Implications for neuroinflammation. Journal of Neuroinflammation 15(1): 25, JANUARY 2018.

2. Zhou Bing, Yoshi Suzuki, Thomas Disanto, Samantha Rubin, Zachary Penfil, Melpo Christofidou-Solomidou, Edward Cantu: Application of Out of Body Lung Perfusion: Yesterday, Today and Tomorrow. Academic Radiology IN REVIEW 2018.

Vladimir V. Shuvaev,Makan Khoshnejad,Katherine W. Pulsipher,Raisa Yu. Kiseleva, Evguenia Arguiri, Jasmina C. Cheung-Lau, Kathleen M. LeFort, Christofidou-Solomidou M, Radu V. Stan, Ivan J. Dmochowski, and Vladimir R. Muzykantov: Caveolar targeting and anti-inflammatory effect of ferritin nanocarriers with spatially controlled configuration of affinity ligand and enzymatic cargo. ACS Nano In Review 2018.

Ralph A. Pietrofesa, Shampa Chatterjee, Sandra Pastorino, Haining Yang, Steven M. Albelda, and Christofidou-Solomidou M: The Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells. International Journal of Molecular Sciences IN REVIEW 2018.

Vladimir V. Shuvaev, Makan Khoshnejad, Katherine W. Pulsipher,Raisa Yu. Kiseleva, Evguenia Arguiri, Christofidou-Solomidou M, Radu V. Stan, Ivan J. Dmochowski, and Vladimir R. Muzykantov: Targeting Superoxide Dismutase to Endothelial Caveolae Profoundly Alleviates Inflammation Caused by Endotoxin Journal of Controlled Release. Journal of Controlled Release DECEMBER 2017.

Velalopoulou, A.; Chatterjee, S.; Pietrofesa, R.A.; Koziol-White, C.; Panettieri, R.A.; Lin, L.; Tuttle, S.; Berman, A.; Koumenis, C.; Christofidou-Solomidou, M.: Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage International Journal of Molecular Sciences 18(2525), NOVEMBER 2017.